35 ) A within-subject analysis revealed a highly significant correlation between antemortem cognitive deterioration and NR1 (a subunit of NMDA-R) mRNA loss in the postmortem temporal cortex (BA 22) of patients with SZ. 36 ) The expression level of NR1 mRNA does not correlate with the age or chronicity of the disorder, 36 ) which suggests that the decrease in NR1 mRNA may not be due to an atrophic change in neural circuitry resulting from prolonged hospitalization or long-term exposure to antipsychotics.
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Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model.
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