Exposure-Response Analysis of Overall Survival for Tremelimumab in Unresectable Malignant Mesothelioma: The Confounding Effect of Disease Status.

Clin Transl Sci · 2019 · PMC6742946 · PMID 30883000

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an apparent trendno p-value reported

Conceptually, if an interaction between PK and a known risk factor of OS was identified, this could translate into an indirect relationship between PK and OS, the resultant being an apparent trend of E‐R when this is explored in a simplified framework, such as KM plots.

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