Characterisation of Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonists in Rodent Pancreatic Beta Cells and Mice.

Effects of N- and C-terminally truncated human and mouse GIP peptides on GIP-induced glucose homeostasis and insulin secretion in mice While administration of hGIP(3-30), h(Pro 3 )GIP(3-30), hGIP(3-42) or hGIP(5-42) in combination with hGIP(1-42) was associated with marginal inhibitory effects on hGIP(1-42)-mediated improvements of glucose homeostasis, this failed to reach significance in terms of individual or overall glucose levels ( Figure 4A , C , E and F ).

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