PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter.

Cell Death Dis · 2019 · PMC6746821 · PMID 31527584

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highly significantno p-value reported

5s ) demonstrated a highly significant increase in PICOT mRNA expression in LUAD compared to LUAD NAT, and a highly significant decrease in CCND2 mRNA expression in LUAD compared to LUAD NAT suggesting that increased PICOT and decreased CCND2 mRNA levels can serve as a tumor marker in LUAD.

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