SNPs common between the current study and the GWAS were, first, grouped around highly significant index SNPs and then pruned out based on linkage disequilibrium (LD) using the ‘clump’ command [ 51 ] in Plink [ 52 ]; a 500 kb range and LD threshold of r 2 ≥ 0.25 were applied.
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Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents.
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