The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.

Sci Rep · 2019 · PMC6748923 · PMID 31530880

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highly significantno p-value reported

A meta-analysis of these data and 5 other data sets showed a highly significant association with CRC risk (OR = 1.50; 95% CI 1.34, 1.66; Pmeta < 10 −10 ; 6640 cases and 8645 controls 5 – 8 .

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