C-banding and AgNOR-staining were still effective complementary methods to indentify chromosomal heteromorphisms and some structural abnormalities in prenatal diagnosis.

However, many investigators have demonstrated that “non clonal chromosome aberrations,” or NCCAs are not “noise” but rather a highly significant feature of the genome system, and the significance of NCCAs will emphasize the ultimate importance of studying heterogeneity in biology, including heteromorphisms and euchromatic variants [ 20 ].

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