Recent insights into the genotype-phenotype relationship from massively parallel genetic assays.

On the other hand, epistasis between naturally occurring mutations in viral and cellular genomes appears to be biased towards positive interactions, with positive epistasis more common between the relatively frequent deleterious mutations and negative epistasis more common between rarely occurring beneficial mutations, that is an overall trend of antagonism (Bonhoeffer, 2004 ; Burch, 2004 ; Caudle et al., 2014 ; H.‐H.

also in 4,871 other papers