Paralog dependency indirectly affects the robustness of human cells.

Mol Syst Biol · 2019 · PMC6757259 · PMID 31556487

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marginally significantno p-value reported

Using the data for 25 heteromers of paralogs, we indeed observed a marginally significant negative correlation with the average CS values (Fig 6 E) of paralog pairs with the strength of interactions, suggesting that codependency indeed could be a mechanism that contributes to the enhanced deleteriousness of paralogs pairs that interact with each other.

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