Autoactivation of small GTPases by the GEF-effector positive feedback modules.

F1000Res · 2019 · PMC6758843 · PMID 31583084

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highly significantno p-value reported

This capability of small GTPases to autoregulate is highly significant as it can potentially explain cell-scale symmetry-breaking events, such as spontaneous cellular polarization 9 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.