Furthermore, human astrocytes are distinct with respect to their size, complexity, and diversity; attributes that can be recapitulated in human:mouse glia chimeras in vivo and may be significant for human neurodegenerative processes (Chen et al. 2015 ; Han et al. 2013 ; Krencik et al. 2011 ; Oberheim et al. 2009 ).
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Uses for humanised mouse models in precision medicine for neurodegenerative disease.
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