Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers.

For statistical evaluation, we computed the mean Spearman correlation ( ρ ) between predicted and measured gene expression profiles on held-out genes for each tumor type and obtained mean ρ = 0.384 ± 0.016 for PSIONIC, a highly significant result ( P < 10 −16 , one-sided Wilcoxon signed-rank test).

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