Safety of Antihypertensive Medications in Pregnancy: Living With Uncertainty.

18 However, if the extended‐release preparation of nifedipine is used, the differences may not be significant in terms of 24‐hour BP control or side effects. 19 The slow onset of amlodipine also implies that antihypertensive effects are delayed (≈8 hours). 16 Limited information suggests that both nifedipine and amlodipine get into breast milk but are unlikely to be associated with adverse fetal effects. 20 Additional questions, not addressed by most studies, assess the impact of drug safety for different maternal diagnoses (eg, preeclampsia versus chronic hypertension) and pregnancy‐related changes in drug pharmacokinetics.

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