highly significantP < 0.0002
21 Comparing our 100 smoking genes identified in C‐SM versus C‐NSM with the top 25 smoking‐related genes identified in this previous meta‐analysis ( n = 25), we found three genes (GPR15, LRRN3, and CLDND1) overlapped, which is highly significant based on a hypergeometric probability test ( P < 0.0002).