In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons.

Even at position +1 the enrichment of ASC in the TAG/HEG class is a barely significant trend (p = 0.041, Wilcoxon signed-rank test) that does not survive Bonferroni correction (p > 0.05/6) ( Fig 2 ).

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There is a highly significant negative correlation between the presence of a stop codon and the distance downstream from the annotated codon.

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