Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence.

Although the proliferative index of Acomys fibroblasts was not significantly altered in response to 150 μM H 2 O 2 (Tukey-HSD, t = 1.93, P = 0.916), after 48 h in culture, 300 μM exposure did produce a marginally significant decrease (18.95%) in EdU + cells (Tukey-HSD, t = 3.32, P = 0.0493) (Fig. 3a and Supplementary Table 6 ).

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