More recently, Hindy et al 28 showed highly significant interaction of smoking with a polygenic risk score (PRS) for CAD with a marked exacerbation of risk in current and to a lesser extent, past smokers.
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2018 George Lyman Duff Memorial Lecture: Genetics and Genomics of Coronary Artery Disease: A Decade of Progress.
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The sentences
The overall contribution of clonal hematopoiesis of indeterminate potential to age-related atherosclerosis remains to be fully understood but is likely to be significant.