Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation.

For both immunogenic stimuli, the results showed a statistically highly significant increase in the transcripts of the pro-inflammatory IL-6 ( Figure 1 A, p < 0.001) and IL-8 ( Figure 1 B, p < 0.001).

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In particular, Ro5-4864 was able to increase the IL-4 levels under both the inflammatory stimuli (in a statistically significant manner following IL-1β treatment and near significance under IL-1β/INF-γ inflammation).

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