Maternal Haplotypes in <i>DHFR</i> Promoter and <i>MTHFR</i> Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS).

Similar to what observed in the whole cohort, MTHFR 677 genotype distribution analyses did not yield significant results, while MTHFR 1298 CC-genotype was underrepresented among children with very-early onset (CC = 2.3%), and when compared with the rest of patients (CC = 9.5%) or with the late-onset subgroup (CC = 11.7%), the differences were of borderline significant value ( P = 0.065 and P = 0.057, respectively) ( Figure 3 b).

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