Papillary Renal Cell Carcinomas Rewire Glutathione Metabolism and Are Deficient in Both Anabolic Glucose Synthesis and Oxidative Phosphorylation.

Cancers (Basel) · 2019 · PMC6770591 · PMID 31484429

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Dramatically Increased Glutathione Levels in pRCC Are Based on Glutamine Consumption Metabolome profiling revealed a highly significant increase in reduced glutathione (GSH, 47-, 68-, 219-fold; fold changes are shown sequentially for type I, II, IIM, respectively) and oxidized glutathione (GSSG, 871-, 847-, 6,707-fold) in pRCC types, Figure 6 A–F, Table S8 ).

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