Impact and Beneficial Critical Points of Clinical Outcome in Corticosteroid Management of Adult Patients With Sepsis: Meta-Analysis and GRADE Assessment.

Front Pharmacol · 2019 · PMC6771229 · PMID 31607929

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a decreasing trendno p-value reported

Overall, there was a dose-response relationship and a decreasing trend on the risk of death existed as the doses or durations of corticosteroid treatment increased.

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marginally significantno p-value reported

Subgroup Analyses A marginally significant reduction in 28-day mortality was observed in the population with septic shock (RR, 0.91; 95% CI, 0.85–0.99; I 2 = 23.3%) and vasopressor-dependent septic shock (RR, 0.88; 95% CI, 0.81–0.96; I 2 = 0.0%) ( Table 2 ).

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