Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction.

Theranostics · 2019 · PMC6771230 · PMID 31588235

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Intriguingly, H19OE mice revealed a significant upregulation in collagen type I alpha 1 (Col1a1) and collagen type I alpha 2 (Col1a2) and an increasing trend in collagen type III alpha 1 (Col3a1) and fibronectin (Fn1), suggesting that H19OE mice underwent severe ECM remodeling (Figure 1 J).

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