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Melatonin is a potential drug for the prevention of bone loss during space flight.

J Pineal Res · 2019 · PMC6771646 · PMID 31286565

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a decreasing trendno p-value reported
15 In addition, in melatonin‐treated perimenopausal women, the ratio of bone resorption marker:formation marker exhibited a decreasing trend. 16 The results indicate that treatment with melatonin is a superior method for suppressing osteoclast activity under microgravity conditions, in addition to on the ground.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.