In addition, module membership (MM) of the individual genetic features in the Green module demonstrated a highly significant correlation with their respective gene significances (GS) for the cancer trait ( r = 0.75, P = 7.1 × 10 −9 , Figure 3C ).
However, multiple other 5′ tRNA halves and 5′ YRNA fragments belonged to modules (i.e., Black, Brown, GreenYellow, and Turquoise) that displayed marginally significant trends (0.05 < P < 0.1) with the cancer trait ( Figure 2B , Supplementary Figures 1 , 2 ). 5′ tRNA-Val-CAC-2-1 Half Is Part of a Key miRNA-Enriched Regulatory Coexpression Module That Targets Genes Involved in the Negative Regulation of the G1/S Transition of the Mitotic Cell Cycle As commented above, we reasoned that miRNAs and 5′ tRNA halves and/or 5′ YRNA fragments that are coregulated and involved in common biological pathways will belong to common coexpression modules detected by the WGCNA method.