Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder.

This underscores the protective role of Prxs, since it suggests that the ability of transferring Prx2 to the erythrocyte cell membrane and of releasing Prx5 in the plasma goes in hand with a milder ASD phenotype. Plasma Prx5 levels are suggestive of ASD Since the difference in Prx5 plasma levels between ASD and TD subjects was highly significant (p < 0.0001 by Mann–Whitney test), we calculated the Receiver Operating Characteristic (ROC) curve.

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