Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study.

MiRNAs with highly significant differences between tissue types and/or tumors subgroups according to tumor grade and receptor status with special focus on the triple-negative breast cancers, were selected for validation.

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We found that miR-17-5p and miR-20a-5p were significantly different between luminal A and triple-negative tumors (p = 0.001 for both miRNAs), borderline significant between luminal A and luminal B cancers for both miR-17-5p and miR-20a-5p with FDR-adjusted p-values of 0.06 and 0.07, respectively, but not between any of the other molecular subgroups or for any of the other miRNAs in the miR-17-92 and miR-106b-5p clusters (Fig. 6 ).

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