In contrast, lixisenatide (ELIXA study) had a neutral effect on CV outcomes [ 44 ], whereas the EXSCEL study assessing the once-weekly exenatide preparation just failed to reach significance for CV benefit with a 9% reduction in events (CI 0.83–1.00; p = 0.06) although a significant reduction in cardiovascular mortality was observed (Table 3 ) [ 45 ].
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Managing Cardiovascular Risk in Type 2 Diabetes: What Do the Cardiovascular Outcome Trials Mean for Australian Practice?
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