Keeping in mind the limited diffusion of antibiotics across disc space, a prolonged antibiotic regimen seems logical. 2 33 34 Many studies have advocated a minimum of 6 weeks of IV therapy, and any duration shorter than that has led to poorer results. 36 Basu et al found a 3-week IV regimen to be effective in the majority of cases; those who failed to respond were operated upon. 5 We started all the patients on a 3-week regimen and administered extended IV doses to those who had suboptimal response (delayed responders) but showed a decreasing trend of biomarkers until the level of CRP reverted to its normal value.
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