Is Alzheimer disease a failure of mobilizing immune defense? Lessons from cognitively fit oldest-old.

Dialogues Clin Neurosci · 2019 · PMC6780355 · PMID 31607776

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a positive trendno p-value reported

130 Initial evaluation from two pooled phase III studies suggest a positive trend toward slowing of cognitive decline in the mild AD subgroup. 131 A monoclonal antibody, mAb158 has high selectivity for soluble Aβ protofibrils, which are toxic to neurons.

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