Low Serum Paraoxonase-1 Activity Associates with Incident Cardiovascular Disease Risk in Subjects with Concurrently High Levels of High-Density Lipoprotein Cholesterol and C-Reactive Protein.

For HR2, PON1 activity was highly significant (protective) in an unadjusted model ( p = 10 −6 ); continued to be highly significant in a collection of models adjusted for gender, age, and a set of covariates added one-at-time; and finally remained significant ( p = 0.0003) in a model adjusted simultaneously for all covariates of the dataset (gender, age, UAE, past CVD, DM, apoB, use of statins, anti-hypertensives, smoking, ethanol use, and eGFR).

also in 132,142 other papers

For HR1, PON1 activity, even in an unadjusted model, did not achieve significance.

also in 1,397 other papers