Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults.

At baseline before exercise, transcripts in the UPR pathway were not remarkably different between young and older adults ( Figure 1A ) and the overall enrichment of the UPR pathway visualized by GSEA was not significantly enriched in older adults, although there was a notable trend (ES = 0.39, FDR = 0.0842) toward increased tonic UPR activation in older adults ( Figure 1B ).

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