CRC progression is a multi-step process that includes various genetic events involving dysregulation of metastasis-associated genes and inactivation of tumor repressor genes.[ 25 ] Recently, a variety of studies have contributed to the development of CRC prognostic models, demonstrating that the abnormalities of clinical and genetic features might be significant predictors for poor clinical outome.[ 26 27 28 ] However, there are limitations to the application of these conclusions.
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COX-2/C-MET/KRAS status-based prognostic nomogram for colorectal cancer: A multicenter cohort study.
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