On the other hand, genotoxicity showed a marginally significant effect on TAS among profiles with dose rank 1 (lowest dose group) and dose rank 6 (highest dose group), where genotoxic chemicals had nominally significantly higher TAS compared to nongenotoxic chemicals ( p -value cutoff > 0.05 ), although following multiple hypothesis testing (FDR method), no groups showed significance at FDR < 0.05 (Figure S2).
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The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity.
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