DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G₂-checkpoint in S-phase irradiated cells.

This observation is highly significant mechanistically, as it suggests that with the transition of a cell from S- to G 2 -phase, regulatory and possibly also structural changes in genome organization occur that profoundly modify the mechanistic underpinnings of the G 2 -checkpoint.

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