Cerebrospinal Fluid and Blood Cytokines as Biomarkers for Multiple Sclerosis: A Systematic Review and Meta-Analysis of 226 Studies With 13,526 Multiple Sclerosis Patients.

Front Neurosci · 2019 · PMC6787166 · PMID 31636528

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0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 0.001actually significant

We next analyzed CSF CXCL13 levels in the RRMS patients given that most of the included studies recruited this subtype of patient, and the meta-analysis showed a highly significant association between elevated CXCL13 levels and RRMS (SMD 0.760; 95%CI, 0.603–1.917; P < 0.001), and no significant association between-study heterogeneity was observed (Q 12 = 12.025; P = 0.444; I 2 = 0.212) in this subgroup.

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