Dietary intakes and biomarker patterns of folate, vitamin B<sub>6</sub>, and vitamin B<sub>12</sub> can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.

Clin Epigenetics · 2019 · PMC6787977 · PMID 31601260

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a positive trendno p-value reported

With respect to the serum level of Hcy, a systemic review and meta-analysis [ 39 ] revealed a positive trend between cognitive impairment and increased Hcy concentration.

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