Distinct immunoglobulin heavy chain variable region gene repertoire and lower frequency of del(11q) in Taiwanese patients with chronic lymphocytic leukaemia.

Independent predicators for inferior OS included un‐mutated IGHV (mutated IGHV : HR = 0·487, 95% CI: 0·262–0·907; P = 0·023), trisomy 12 (HR = 2·301, 95% CI: 1·150–3·951; P = 0·007), TP53 disruption (HR = 3·667, 95% CI: 2·025–6·639; P < 0·0001), SF3B1 mutations (HR = 2·786, 95% CI: 1·239–6·267; P = 0·013) and at a borderline significant level for BCR subset 8 (HR = 2·307, 95% CI: 0·896–5·938; P = 0·083) (Table 3 ).

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