Cornea nerve fibre state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation.

The correlation still existed when the treatment responder groups were analysed separately, but at a borderline significant level probably due to the smaller sample size (tapentadol responder group: r 2 = 0.78, p = 0.047; placebo responder group r 2 = 0.76, p = 0.055; Figure 4 a,b).

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A highly significant correlation was observed between absolute pain scores and corresponding CPM% values per visit when all treatment responders (tapentadol and placebo) were taken together ( r 2 = 0.60, p = 0.008).

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