Concluding Remarks and Future Directions Many epigenetic modifications are small and ubiquitous, suggesting that their biophysical contributions to gene regulation can be significant. In particular, they often play direct roles in regulating the thermodynamic and kinetic stabilities of nucleosomes and nucleosome stacks and, subsequently, DNA-histone and nucleosome-nucleosome interactions. These roles are highly significant points of investigation, as the accurate regulation of the intra- and internucleosomal interactions between histone and DNA are critical to maintaining the healthy life and proliferation of a cell.
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