Gene set enrichment analysis (GSEA) showed a highly significant enrichment of a p53 target gene signature (MSigDB P53_ downstream _ pathway ) in p53 +/+ cells compared to either p53 EE/EE or p53 −/− MEFs, but no enrichment in p53 EE/EE versus p53 −/− MEFs (Fig 1 D).
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Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses.
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