The set of SSV-associated genes for each cancer type was distinct from those of the other cancer types (Additional file 1 : Figure S4A). Interestingly, when we compared the cancer type-specific SSV-gene associations with differential DNA methylation patterns (involving n = 1482 cases out of the 2334), we observed highly significant overlaps, between the genes with positive correlations between expression and nearby SSV breakpoint for a given cancer type and the genes with high overall DNA methylation being associated with that same cancer type (Fig. 3 c and Additional file 1 : Figure S4B).
← all excerpts
Global impact of somatic structural variation on the DNA methylome of human cancers.
1
—
—