A highly significant relationship between genome size and GC content, length of intergenic spacers, coding density, mean CDS length, number of overlapping CDS, paralogs, and numbers of genes involved in sensing of the environment (i.e., histidine kinases and sigma factors) was evident (Fig. 2 ).
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Evolution in action: habitat transition from sediment to the pelagial leads to genome streamlining in Methylophilaceae.
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