Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m<sup>6</sup>A reader YTHDF3.

Remarkably, intersection analysis of KEGG pathway analysis for differentially expressed genes both in YAP knockdown and GAS5 up-regulation groups revealed a highly significant overlap of 543 common targets (FC > 2; p -value< 0.05), mostly deregulated in the same direction and enriched in the Hippo pathway, strongly supporting the key role of GAS5 in YAP signaling (Fig. 2 h-i).

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