A case series of adult T-cell leukemia-lymphoma, associated with human T-cell leukemia virus type-1, at a single center in a non-viral-endemic metropolitan area.

Comprehensive molecular analysis revealed that many somatic alterations in ATL cells largely converged on T-cell receptor NF-κB signaling and other T cell-related pathways, and demonstrated a highly significant overlap with the Tax interactome, in addition to the frequent involvement of essential components of antigen presentation and immune surveillance. 8 It is estimated that approximately 10 million people are infected with HTLV-1 worldwide, with endemic foci in the Caribbean basin, South America, sub-

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