Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.

Nat Commun · 2019 · PMC6800452 · PMID 31628327

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highly significantno p-value reported

Spearman’s rank correlation analysis between the KYN/TRP ratios and QA levels from all individuals in Cohort 3 demonstrated a highly significant correlation between these two parameters (Fig. 1e and Supplementary Data 8 ).

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