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A Prospective Six-Month Study of Chronic Pain Sufferers: A Novel OTC Neuromodulation Therapy.

Pain Res Manag · 2019 · PMC6800946 · PMID 31687056

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highly significantno p-value reported
These include the highly significant and often multiple adverse side effects from opiate-based analgesics that are correlated with higher doses and long-term use [ 32 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.