highly significantp < 0.001
The absence of shadowing and spiculation remained highly significant predictors of pCR on univariate analysis of the HER-2 positive group, in addition to small ultrasound size (AUC = 0.713, p < 0.001) (Fig. 2) and absence of microcalcification (29 of 74; 39% vs. 17 of 80; 21% p < 0.02) (Table 2 ).