Notably, patient QoL remained stable for most functional and symptom scales in both arms, and a positive trend towards a lower risk of the QoL deterioration was reported for the patients receiving trifluridine/tipiracil. 9 Use of combination regimens of fluoropyrimidines with other chemotherapeutic agents (ie, 5-FU, leucovorin and oxaliplatin) and/or molecularly targeted agents has lengthened survival time in patients with metastatic CRC and GC, compared with earlier treatment with 5-FU alone.
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Extension of the European Medicines Agency (EMA) approval of trifluridine/tipiracil for gastric cancer.
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