Barely Significant
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Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study.

Sci Rep · 2019 · PMC6803623 · PMID 31636347

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borderline significantno p-value reported
In a study on major depressive disorder where the authors randomized 12 patients to naltrexone 1 mg/day or placebo, there were borderline significant improvements in some clinical depression measures 4 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.