Mitochondrial DNA Haplogroup N9a Negatively Correlates with Incidence of Hepatocellular Carcinoma in Northern China.

In northern China, haplogroup M and its defining SNP, m.T489C, were positively associated (albeit with marginal significance) with later age-at-onset of HCC, 18 although haplogroup M7 was negatively associated with HCC in eastern China. 19 In this study, we found that haplogroup N9a was negatively associated with HCC in northern China, but neither haplogroup M7 nor macro-mtDNA haplogroup M (defined by m.10400C > T) was associated with HCC in the same region.

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